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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CASP9
All Species:
8.18
Human Site:
S195
Identified Species:
15
UniProt:
P55211
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55211
NP_001220.2
416
46281
S195
E
K
L
R
R
R
F
S
S
L
H
F
M
V
E
Chimpanzee
Pan troglodytes
Q5IS54
277
31588
E84
T
F
R
N
L
K
Y
E
V
R
N
K
N
D
L
Rhesus Macaque
Macaca mulatta
XP_001082859
416
46192
S195
E
K
L
Q
R
R
F
S
L
L
H
F
M
V
E
Dog
Lupus familis
XP_865164
414
45235
C194
E
K
L
Q
R
R
F
C
L
L
R
F
T
V
E
Cat
Felis silvestris
Mouse
Mus musculus
P29594
452
50642
K234
T
T
L
V
T
L
F
K
L
L
G
Y
N
V
H
Rat
Rattus norvegicus
P55215
452
50709
K234
T
T
L
V
T
L
F
K
L
L
G
Y
N
V
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520982
366
40213
N167
E
E
M
V
K
A
L
N
K
L
A
K
K
D
H
Chicken
Gallus gallus
Q98943
424
47941
K205
A
S
L
E
L
L
F
K
H
L
G
Y
Q
V
T
Frog
Xenopus laevis
P55866
282
32106
T89
L
K
L
H
E
T
F
T
G
L
G
Y
E
V
M
Zebra Danio
Brachydanio rerio
NP_001007405
436
48445
K206
D
K
L
E
K
R
F
K
A
L
N
F
E
V
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02002
323
35908
D128
H
K
D
C
K
L
R
D
I
L
K
H
V
G
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P42573
503
56598
R274
D
N
L
T
N
L
F
R
C
M
G
Y
T
V
I
Sea Urchin
Strong. purpuratus
XP_799258
437
48470
T196
R
N
L
E
N
I
F
T
Q
L
D
F
D
V
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
22.8
93.9
76.9
N.A.
28.9
28.3
N.A.
52.8
31.1
22.6
47.2
N.A.
22.1
N.A.
21.6
32.2
Protein Similarity:
100
35.8
96.8
84.1
N.A.
46.9
46.2
N.A.
65.6
48.3
38.7
64.2
N.A.
35.8
N.A.
37.5
51
P-Site Identity:
100
0
86.6
66.6
N.A.
26.6
26.6
N.A.
13.3
26.6
33.3
46.6
N.A.
13.3
N.A.
20
33.3
P-Site Similarity:
100
20
93.3
73.3
N.A.
33.3
33.3
N.A.
40
33.3
46.6
73.3
N.A.
33.3
N.A.
40
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
8
0
0
8
0
8
0
0
0
0
% A
% Cys:
0
0
0
8
0
0
0
8
8
0
0
0
0
0
0
% C
% Asp:
16
0
8
0
0
0
0
8
0
0
8
0
8
16
0
% D
% Glu:
31
8
0
24
8
0
0
8
0
0
0
0
16
0
24
% E
% Phe:
0
8
0
0
0
0
77
0
0
0
0
39
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
8
0
39
0
0
8
0
% G
% His:
8
0
0
8
0
0
0
0
8
0
16
8
0
0
24
% H
% Ile:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
8
% I
% Lys:
0
47
0
0
24
8
0
31
8
0
8
16
8
0
8
% K
% Leu:
8
0
77
0
16
39
8
0
31
85
0
0
0
0
8
% L
% Met:
0
0
8
0
0
0
0
0
0
8
0
0
16
0
8
% M
% Asn:
0
16
0
8
16
0
0
8
0
0
16
0
24
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
16
0
0
0
0
8
0
0
0
8
0
0
% Q
% Arg:
8
0
8
8
24
31
8
8
0
8
8
0
0
0
0
% R
% Ser:
0
8
0
0
0
0
0
16
8
0
0
0
0
0
0
% S
% Thr:
24
16
0
8
16
8
0
16
0
0
0
0
16
0
16
% T
% Val:
0
0
0
24
0
0
0
0
8
0
0
0
8
77
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
0
39
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _